Journal article
A144 CHRONIC DSS LEADS TO ALTERED EXPRESSION OF IRAK4/TPL2 PATHWAYS IN UC-COLONIZED MICE
Abstract
AbstractBackground
Ulcerative colitis (UC) is one of two forms of inflammatory bowel disease (IBD). The exact cause of IBD is unknown but altered host-microbe interactions and genetic susceptibility are involved in its pathogenesis. Many patients with IBD do not respond to biological therapies targeting single cytokines, therefore new therapies that target common immune pathways are being developed and need to be tested in relevant preclinical …
Authors
Hann A; Santiago A; Galipeau HJ; Constante M; Jackson K; Bercik P; Verdu E
Journal
Journal of the Canadian Association of Gastroenterology, Vol. 5, No. Supplement_1, pp. 17–18
Publisher
Oxford University Press (OUP)
Publication Date
February 21, 2022
DOI
10.1093/jcag/gwab049.143
ISSN
2515-2084