This chapter presents a case scenario of a 72‐year‐old male patient who has been managed nonoperatively for years for his right knee osteoarthritis, and is now having worsening pain. He undergoes an uneventful total knee arthroplasty (TKA). The analgesic options following TKA include pharmacological and nonpharmacological techniques. Liposomal bupivacaine is intended to prolong the action of bupivacaine employed for regional analgesia. A Cochrane review found no benefits of continuous passive motion on function, pain, or quality of life after primary TKA. Given the current opioid crisis globally and especially in North America, any strategies which can help to minimize perioperative opioid use are important to identify. Despite a technically well‐performed surgery, a substantial proportion of patients suffer from persistent postoperative pain and decreased quality of life after TKA. The chapter also provides recommendations for implementing evidence‐based practice in the clinical setting.