Journal article
Design Considerations for Intratracheal Delivery Devices to Achieve Proof-of-Concept Dry Powder Biopharmaceutical Delivery in Mice
Abstract
PurposeIntratracheal delivery and consistent dosing of dry powder vaccines is especially challenging in mice. To address this issue, device design of positive pressure dosators and actuation parameters were assessed for their impacts on powder flowability and in vivo dry powder delivery.MethodsA chamber-loading dosator assembled with stainless-steel, polypropylene or polytetrafluoroethylene needle-tips was used to determine optimal actuation …
Authors
Manser M; Jeyanathan V; Jeyanathan M; Feng X; Dolovich MB; Xing Z; Cranston ED; Thompson MR
Journal
Pharmaceutical Research, Vol. 40, No. 5, pp. 1165–1176
Publisher
Springer Nature
Publication Date
5 2023
DOI
10.1007/s11095-023-03492-2
ISSN
0724-8741