Journal article
RADI-04. PRETREATMENT VOLUME OF MRI-DETERMINED WHITE MATTER INJURY (WMI) PREDICTS COGNITIVE DECLINE AFTER HIPPOCAMPAL AVOIDANT (HA) WBRT FOR BRAIN METASTASES: SECONDARY ANALYSIS OF NRG ONCOLOGY RTOG 0933
Abstract
Abstract
PURPOSE: RTOG 0933 demonstrated benefits to memory following HA-WBRT, supporting the hypothesis of hippocampal radiosensitivity and associated memory specificity. However, some patients demonstrated cognitive decline, suggesting mechanisms outside hippocampal radiosensitivity playing a role. WMI has been implicated in RT-induced cognitive decline. This secondary analysis explored the relationship between pre-treatment …
Authors
Bovi J; Pugh S; Sabesevitz D; Robinson C; Paulson E; Mehta M; Gondi V; Kundapur V; Pinover W; Chao S
Journal
Neuro-Oncology Advances, Vol. 1, No. Supplement_1, pp. i22–i22
Publisher
Oxford University Press (OUP)
Publication Date
August 12, 2019
DOI
10.1093/noajnl/vdz014.097
ISSN
0801-3284