Thermogenesis in CD-1 mice after combined chronic hypoxia and cold acclimation

Many small mammals thermoregulate through shivering in muscle and/or non-shivering thermogenesis (NST) via brown adipose tissue (BAT) by the actions of mitochondrial uncoupling proteins (UCPs). An up-regulation of these mechanisms would be advantageous in a cold environment but not in conditions of low oxygen as it leads to needless increases in energy expenditure. We examined the chronic effect of 4 weeks of exposure to hypobaric hypoxia (H, …