A novel P,O-type phosphorinane ligand for the Suzuki–Miyaura cross-coupling of aryl chlorides

The Pd-mediated Suzuki–Miyaura cross-coupling of substituted and unsubstituted aryl chlorides with phosphorinane ligands was investigated uncovering an interesting ligand effect. The scope of the most effective 4-hydroxyl-substituted phosphorinane ligand in Suzuki cross-coupling with challenging aryl chlorides is described.