Journal article
Stereochemical studies on the proposed spiro intermediate for the biosynthesis of the natural porphyrins: determination by a novel X-ray method of the absolute configuration of the spirolactam which inhibits cosynthetase
Abstract
A novel X-ray analysis, combined with correlations by circular dichroism, has been used to establish the (R)-configuration at the stereocentre in that enantiomer of the spirolactam 4 which strongly inhibits uroporphyrinogen III synthase.
Authors
Spivey AC; Capretta A; Frampton CS; Leeper FJ; Battersby AR
Journal
Chemical Communications, Vol. 0, No. 17, pp. 1789–1790
Publisher
Royal Society of Chemistry (RSC)
Publication Date
1995
DOI
10.1039/c39950001789
ISSN
1359-7345