Journal article
A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) mainly results from mutations in the PKD1 gene, which encodes polycystin 1. It is the most common inherited kidney disease and is characterized by a progressive bilateral increase in cyst number and size, often leading to kidney failure. The cellular energy sensor and regulator adenosine monophosphate stimulated protein kinase (AMPK) has been implicated as a promising new therapeutic target. …
Authors
Dagorn PG; Buchholz B; Kraus A; Batchuluun B; Bange H; Blockken L; Steinberg GR; Moller DE; Hallakou-Bozec S
Journal
Kidney International, Vol. 103, No. 5, pp. 917–929
Publisher
Elsevier
Publication Date
5 2023
DOI
10.1016/j.kint.2023.01.026
ISSN
0085-2538