Journal article
The synthesis, NMR and X-ray analysis of tris(1-ethyl-2-isopropylimidazol-5-yl)phosphine gold (I)-2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside, a bifunctional auranofin analogue
Abstract
A derivative of auranofin, a drug used in the treatment of rheumatoid arthritis, was synthesised and examined by NMR spectroscopy and X-ray crystallography. The derivative, which contains a trisimidazole phosphine, was designed to complex hard metals in addition to binding to the gold(I) centre.
Authors
Bell RA; Lock CJL; Scholten C; Valliant JF
Journal
Inorganica Chimica Acta, Vol. 274, No. 2, pp. 137–142
Publisher
Elsevier
Publication Date
June 1998
DOI
10.1016/s0020-1693(97)06039-8
ISSN
0020-1693