Journal article
Oncolytic BHV-1 Is Sufficient to Induce Immunogenic Cell Death and Synergizes with Low-Dose Chemotherapy to Dampen Immunosuppressive T Regulatory Cells
Abstract
Immunogenic cell death (ICD) can switch immunologically "cold" tumors "hot", making them sensitive to immune checkpoint inhibitor (ICI) therapy. Many therapeutic platforms combine multiple modalities such as oncolytic viruses (OVs) and low-dose chemotherapy to induce ICD and improve prognostic outcomes. We previously detailed many unique properties of oncolytic bovine herpesvirus type 1 (oBHV) that suggest widespread clinical utility. Here, we …
Authors
Davola ME; Cormier O; Vito A; El-Sayes N; Collins S; Salem O; Revill S; Ask K; Wan Y; Mossman K
Journal
Cancers, Vol. 15, No. 4,
Publisher
MDPI
DOI
10.3390/cancers15041295
ISSN
2072-6694