Journal article
Childhood Brain Tumors: A Review of Strategies to Translate CNS Drug Delivery to Clinical Trials
Abstract
Brain and spinal tumors affect 1 in 1000 people by 25 years of age, and have diverse histological, biological, anatomical and dissemination characteristics. A mortality of 30-40% means the majority are cured, although two-thirds have life-long disability, linked to accumulated brain injury that is acquired prior to diagnosis, and after surgery or chemo-radiotherapy. Only four drugs have been licensed globally for brain tumors in 40 years and …
Authors
Rahman R; Janowski M; Killick-Cole CL; Singleton WGB; Campbell E; Walczak P; Khatua S; Faltings L; Symons M; Schneider JR
Journal
Cancers, Vol. 15, No. 3,
Publisher
MDPI
DOI
10.3390/cancers15030857
ISSN
2072-6694