Journal article
Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway
Abstract
Oxytocin (OT) plays an important role in pain modulation and antinociception in the central nervous system. However, little is known about its peripheral effects. This study was conducted to investigate the effect of OT on the electrical properties of neurons in the dorsal root ganglia (DRG) and the underlying mechanisms. DRG neurons from adult rats were acutely dissociated and cultured. Intracellular Ca(2+) was determined by fluorescent …
Authors
Gong L; Gao F; Li J; Li J; Yu X; Ma X; Zheng W; Cui S; Liu K; Zhang M
Journal
Neuroscience, Vol. 289, , pp. 417–428
Publisher
Elsevier
Publication Date
March 2015
DOI
10.1016/j.neuroscience.2014.12.058
ISSN
0306-4522