Journal article
A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling
Abstract
BackgroundTGFβ1 is a major profibrotic mediator in chronic kidney disease (CKD). Its direct inhibition, however, is limited by adverse effects. Inhibition of activins, also members of the TGFβ superfamily, blocks TGFβ1 profibrotic effects, but the mechanism underlying this and the specific activin(s) involved are unknown.MethodsCells were treated with TGFβ1 or activins A/B. Activins were inhibited generally with follistatin, or specifically …
Authors
Soomro A; Khajehei M; Li R; O’Neil K; Zhang D; Gao B; MacDonald M; Kakoki M; Krepinsky JC
Journal
Cellular & Molecular Biology Letters, Vol. 28, No. 1,
Publisher
Springer Nature
DOI
10.1186/s11658-023-00424-1
ISSN
1425-8153