Journal article
Thiopurine S-methyltransferase testing for averting drug toxicity: a meta-analysis of diagnostic test accuracy
Abstract
Thiopurine S-methyltransferase (TPMT) deficiency increases the risk of serious adverse events in persons receiving thiopurines. The objective was to synthesize reported sensitivity and specificity of TPMT phenotyping and genotyping using a latent class hierarchical summary receiver operating characteristic meta-analysis. In 27 studies, pooled sensitivity and specificity of phenotyping for deficient individuals was 75.9% (95% credible interval …
Authors
Zur RM; Roy LM; Ito S; Beyene J; Carew C; Ungar WJ
Journal
The Pharmacogenomics Journal, Vol. 16, No. 4, pp. 305–311
Publisher
Springer Nature
Publication Date
August 2016
DOI
10.1038/tpj.2016.37
ISSN
1470-269X
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Area Under CurveDrug HypersensitivityDrug-Related Side Effects and Adverse ReactionsGenetic Predisposition to DiseaseHumansMethyltransferasesPharmacogenomic TestingPharmacogenomic VariantsPhenotypePredictive Value of TestsPurine-Pyrimidine Metabolism, Inborn ErrorsPurinesROC CurveReproducibility of Results