Journal article
A diffusion theory model of spatially resolved fluorescence from depth-dependent fluorophore concentrations
Abstract
A photon diffusion model has been developed to calculate the steady-state spatially resolved fluorescence from pencil beam excitation in layered tissue. The model allows the calculation of both the excitation reflectance and the fluorescence escape for an arbitrary continuous depth distribution of tissue optical properties and fluorophore concentration. The validity of this model was verified by comparison with Monte Carlo simulations and …
Authors
Hyde DE; Farrell TJ; Patterson MS; Wilson BC
Journal
Physics in Medicine and Biology, Vol. 46, No. 2, pp. 369–383
Publisher
IOP Publishing
Publication Date
February 1, 2001
DOI
10.1088/0031-9155/46/2/307
ISSN
0031-9155