Journal article
Characterization of Photofrin photobleaching for singlet oxygen dose estimation during photodynamic therapy of MLL cells in vitro
Abstract
A singlet oxygen dose model is developed for PDT with Photofrin. The model is based on photosensitizer photobleaching kinetics, and incorporates both singlet oxygen and non-singlet oxygen mediated bleaching mechanisms. To test our model, in vitro experiments were performed in which MatLyLu (MLL) cells were incubated in Photofrin and then irradiated with 532 nm light. Photofrin fluorescence was monitored during treatment and, at selected fluence …
Authors
Dysart JS; Patterson MS
Journal
Physics in Medicine and Biology, Vol. 50, No. 11, pp. 2597–2616
Publisher
IOP Publishing
Publication Date
June 7, 2005
DOI
10.1088/0031-9155/50/11/011
ISSN
0031-9155