Journal article
Modeling of photosensitizer fluorescence emission and photobleaching for photodynamic therapy dosimetry.
Abstract
Photon diffusion theory was used to model photobleaching and tissue necrosis resulting from broad-beam therapeutic light irradiation of tissue containing a photosensitizer. The photosensitizer fluorescence signal at the tissue surface was simulated with both broad-beam and pencil-beam excitation. The relationship between the decreasing fluorescence signal and the increasing depth of tissue photodynamic damage during treatment was examined. By …
Authors
Farrell TJ; Hawkes RP; Patterson MS; Wilson BC
Journal
Applied Optics, Vol. 37, No. 31, pp. 7168–7183
Publisher
Optica Publishing Group
Publication Date
November 1, 1998
DOI
10.1364/ao.37.007168
ISSN
1559-128X