Initial Evidence that OPRM1 Genotype Moderates Ventral and Dorsal Striatum Functional Connectivity During Alcohol Cues

BACKGROUND: Endogenous opioids and striatal dopamine have been implicated in cue-induced alcohol craving and have been hypothesized to play a role in goal-directed, as opposed to habitual, alcohol use. This initial study examines dorsal and ventral striatal functional connectivity during alcohol-cue processing as a function of the A118G single-nucleotide polymorphism of the mu-opioid receptor (OPRM1) gene. METHODS: Seventeen individuals with …