Functional impact of IBS-D microbiota on the gut-brain axis

Irritable Bowel Syndrome (IBS) is a common disorder characterized by altered gut function and frequent psychiatric co-morbidity. Although altered intestinal microbiome profiles have been documented, their relevance to the clinical expression of IBS is unknown. To assess the functional role of the microbiota, we colonized germ-free mice with fecal microbiota from healthy controls or from IBS patients with diarrhea (IBS-D) with or without …