Two‐Component Signal Transduction Systems: Structure‐Function Relationships and Mechanisms of Catalysis

Two‐component systems are signal‐transducing ATPases that use energy released from ATP hydrolysis to effect responses to changing environmental conditions. The phosphorylated aspartate is contained within another type of protein termed a response regulator, which undergoes a phosphorylation‐induced conformational change that serves to elicit a response. The histidine kinase domain is invariably flanked by sequences that are not conserved within …