Gender‐based differential infiltration of CRP from the blood into skeletal muscle

We conducted 3 studies to profile C‐reactive protein (CRP), a marker of systemic inflammation, in serum and muscle (vastus lateralis) and its response to endurance exercise in men and women. In study 1, we found serum CRP to be 2.9 fold higher in sedentary lean women (mean ± SD; 1096 ± 1241 ng/mL) vs. men (382 ± 366 ng/mL) (P = 0.006), in contrast to muscle CRP which was 40% higher in men (0.83 ± 0.21 ng/mg protein) vs. women (0.61 ± 0.13 ng/mg …