Journal article
Abstract 80: Interleukin 15 Plays an Important Role in the Development of Atherosclerosis in Apolipoprotein E Knockout Mice
Abstract
IL-15 is an essential cytokine for the development of NK and CD8+T cells and also involved in activation of inflammation in macrophages. Therefore, we hypothesized that IL-15 may affect the development of atherosclerosis via regulating immune/inflammatory cells. To test this we generated apoE KO mice that either overexpressed (il-15TgapoE-/-) or lacked either one (il-15+/-apoE-/-) or both copies (il-15-/-apoE-/-) of the IL-15 gene. Deficiency …
Authors
Dadoo O; Ashkar A; Richards C; Trigatti B
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 32, No. suppl_1,
Publisher
Wolters Kluwer
Publication Date
May 2012
DOI
10.1161/atvb.32.suppl_1.a80
ISSN
1079-5642