The growth hormone axis, feeding, and central allocative regulation: lessons from giant transgenic growth hormone mice

Lifetime consumption rates of male transgenic growth hormone (GH) mice and normal controls were measured on either a 38% protein diet (HP), the standard rodent diet (STD) (23.5% protein), or the standard diet supplemented with a free choice of sucrose (CARB). On STD, daily intake of normal mice increased little at sizes greater than 20 g, but larger transgenic mice ate progressively more. Both kinds of mice showed declining daily mass-specific …