Accelerated aging of giant transgenic mice is associated with elevated free radical processes

Transgenic growth hormone mice lived half as long as normal on a 23% protein diet. Longevities of both transgenic and control mice on a 38% protein diet were half those on 23% protein food. We hypothesized that transgenic mice are energetically constrained by their rapid growth, so energy supplements might improve "longevity assurance investments." As predicted, sucrose supplements extended the longevity of transgenic females (from a mean of …