A84 INTERACTION OF SEROTONIN WITH PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-GAMMA IN ANTIMICROBIAL PEPTIDE PRODUCTION IN GUT

Serotonin (5-hydroxytryptamine; 5-HT), is a neurotransmitter and hormone that regulates various gut physiological functions. Enterochromaffin (EC) cells are the main producer of gut 5-HT, and tryptophan hydroxylase 1 (Tph1) is the rate-limiting enzyme of 5-HT biosynthesis. There is increasing evidence that gut function as well as pathology rely on interactions with gut microbiota. β-defensins are major class of antimicrobial peptides (AMPs) …