Journal article
Cell surface GRP78 activation by anti‐GRP78 autoantibodies in relation to prostate tumour growth via tissue factor activation.
Abstract
Background Prostate cancer (PC) presentation is associated with the production of anti‐GRP78 autoantibodies that enhance tissue factor (TF) expression and procoagulant activity (PCA). We and others observed that GRP78 is expressed on the surface of PC cells where it functions as a signaling receptor to promote cell proliferation and survival. Normally, GRP78 is an endoplasmic reticulum resident chaperon that ensure the proper folding of newly …
Authors
Al‐Hashimi A; Shayegan B; Austin R
Journal
The FASEB Journal, Vol. 32, No. S1, pp. 804.13–804.13
Publisher
Wiley
Publication Date
April 2018
DOI
10.1096/fasebj.2018.32.1_supplement.804.13
ISSN
0892-6638