Journal article
Lipopolysaccharide‐Induced Bone Loss in Rodent Models: A Systematic Review and Meta‐Analysis
Abstract
Osteoporosis has traditionally been characterized by underlying endocrine mechanisms, though evidence indicates a role of inflammation in its pathophysiology. Lipopolysaccharide (LPS), a component of gram-negative bacteria that reside in the intestines, can be released into circulation and stimulate the immune system, upregulating bone resorption. Exogenous LPS is used in rodent models to study the effect of systemic inflammation on bone, and …
Authors
Bott KN; Feldman E; de Souza RJ; Comelli EM; Klentrou P; Peters SJ; Ward WE
Journal
Journal of Bone and Mineral Research, Vol. 38, No. 1, pp. 198–213
Publisher
Oxford University Press (OUP)
Publication Date
December 1, 2020
DOI
10.1002/jbmr.4740
ISSN
0884-0431