Journal article
Comprehensive Profiling of Free and Conjugated Estrogens by Capillary Electrophoresis–Time of Flight/Mass Spectrometry
Abstract
The biological activity of estrogens is tightly regulated by regioselective phase I/II metabolic transformations that are critical to human health. Current methods for analysis of urinary estrogens are limited by complicated sample pretreatment and/or inadequate specificity for free estrogens and their glucuronide/sulfate conjugates that vary widely in their intrinsic polarity. In this work, direct speciation of intact estrogen conjugates and …
Authors
Kuehnbaum NL; Britz-McKibbin P
Journal
Analytical Chemistry, Vol. 83, No. 21, pp. 8063–8068
Publisher
American Chemical Society (ACS)
Publication Date
November 1, 2011
DOI
10.1021/ac201980w
ISSN
0003-2700