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Multiplexed separations for biomarker discovery in...
Journal article

Multiplexed separations for biomarker discovery in metabolomics: Elucidating adaptive responses to exercise training

Abstract

High efficiency separations are needed to enhance selectivity, mass spectral quality, and quantitative performance in metabolomic studies. However, low sample throughput and complicated data preprocessing remain major bottlenecks to biomarker discovery. We introduce an accelerated data workflow to identify plasma metabolite signatures of exercise responsiveness when using multisegment injection-capillary electrophoresis-mass spectrometry …

Authors

Kuehnbaum NL; Gillen JB; Kormendi A; Lam KP; DiBattista A; Gibala MJ; Britz-McKibbin P

Journal

Electrophoresis, Vol. 36, No. 18, pp. 2226–2236

Publisher

Wiley

Publication Date

September 2015

DOI

10.1002/elps.201400604

ISSN

0173-0835