Journal article
Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds
Abstract
A family of compounds based upon the chemical structure of valproate were synthesized and assayed for their ability to inhibit glycogen synthase kinase (GSK)-3 alpha and beta activity in vitro. This data is correlated to the known anti-convulsant properties of these compounds in order to determine the potential role of GSK-3 inhibition in the therapeutic efficacy of these drugs.
Authors
Werstuck GH; Kim AJ; Brenstrum T; Ohnmacht SA; Panna E; Capretta A
Journal
Bioorganic & Medicinal Chemistry Letters, Vol. 14, No. 22, pp. 5465–5467
Publisher
Elsevier
Publication Date
November 2004
DOI
10.1016/j.bmcl.2004.09.013
ISSN
0960-894X