Journal article
CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase
Abstract
Recently, it has been shown that carbon monoxide (CO)-releasing molecule (CORM)-released CO can suppress inflammation. In this study, we assessed the effects and potential mechanisms of a ruthenium-based water-soluble CO carrier [tricarbonylchloroglycinate-ruthenium(II) (CORM-3)] in the modulation of polymorphonuclear leukocyte (PMN) inflammatory responses in an experimental model of sepsis. Sepsis in mice was induced by cecal ligation and …
Authors
Mizuguchi S; Stephen J; Bihari R; Markovic N; Suehiro S; Capretta A; Potter RF; Cepinskas G
Journal
AJP Heart and Circulatory Physiology, Vol. 297, No. 3, pp. h920–h929
Publisher
American Physiological Society
Publication Date
September 2009
DOI
10.1152/ajpheart.00305.2009
ISSN
0363-6135
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCarbon MonoxideCell AdhesionCell Migration Assays, LeukocyteCell MovementCells, CulturedDisease Models, AnimalEndothelial CellsEndothelium, VascularHumansLeukocyte ElastaseLipopolysaccharidesLungMiceMice, Inbred C57BLNeutrophilsOrganometallic CompoundsPeritonitisReactive Oxygen SpeciesSepsisUmbilical Veins