Renal function and hyperfiltration capacity in lead smelter workers with high bone lead.

OBJECTIVE: The study was undertaken to assess whether the changes in urinary excretion of eicosanoids (a decrease of 6-keto-PGF1 alpha and PGF2 and an increase of thromboxane) previously found in lead (Pb) exposed workers may decrease the renal haemodynamic response to an acute oral protein load. METHODS: The renal haemodynamic response was estimated by determining the capacity of the kidney to increase the glomerular filtration rate (in terms …