Journal article
Acyclic Stereoselective Boron Alkylation Reactions for the Asymmetric Synthesis of β-Substituted α-Amino Acid Derivatives
Abstract
Optically active syn- or anti-beta-substituted-alpha-amino acid derivatives are prepared in 94 to >/=99% ee and 66-98% ds by reaction of the Schiff base acetate of glycine tert-butyl ester with chiral, nonracemic B-alkyl-9-BBN derivatives in the presence of the Cinchona alkaloid, cinchonidine (CdOH) or cinchonine (CnOH), base, and lithium chloride.
Authors
O'Donnell MJ; Cooper JT; Mader MM
Journal
Journal of the American Chemical Society, Vol. 125, No. 9, pp. 2370–2371
Publisher
American Chemical Society (ACS)
Publication Date
March 1, 2003
DOI
10.1021/ja0298794
ISSN
0002-7863