Journal article
Trimethoprim-sulfamethoxazole and the risk of a hospital encounter with hyperkalemia: a matched population-based cohort study
Abstract
BACKGROUND: Trimethoprim-sulfamethoxazole (TMP-SMX) can cause hyperkalemia by reducing renal potassium excretion. We assessed the risk of hyperkalemia after initiating TMP-SMX versus amoxicillin and determined if this risk is modified by a patient's baseline kidney function [estimated glomerular filtration rate (eGFR)].
METHODS: We conducted a population-based cohort study in Ontario, Canada involving adults ≥66 years of age newly treated with …
Authors
Hwang YJ; Muanda FT; McArthur E; Weir MA; Sontrop JM; Lam NN; Garg AX
Journal
Nephrology Dialysis Transplantation, Vol. 38, No. 6, pp. 1459–1468
Publisher
Oxford University Press (OUP)
Publication Date
May 31, 2023
DOI
10.1093/ndt/gfac282
ISSN
0931-0509