Pain and Opioid Use Outcome Measures in Knee Arthroplasty Randomized Trials: A Protocol for a Methodological Review

Background: Osteoarthritis (OA) is one of the most common degenerative joint diseases that occurs in the elderly population. Total knee arthroplasty is a recognized treatment for end-stage knee OA and is effective in managing pain and improving function. However, postoperative pain and opioid use continue to be major challenges. Clinical trials aiming to study interventions to decrease these twin challenges have used different priorities and …