137: Genes Increasing Glucose Levels in Early Childhood Provide Support for the Fetal Insulin Hypothesis: Results from the Family Study

Type 2 diabetes (T2D) is a global epidemic that currently affects 347 million people worldwide. Many of the abnormalities that characterize this disorder, particularly perturbations in glucose levels, appear to begin as early as 12 years of age. One proposition to explain its pathogenesis, the ‘fetal insulin hypothesis’, suggests that genetically determined impaired insulin secretion or action leads to poor insulin-mediated fetal growth and …