Journal article
PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal
Abstract
Hematopoietic stem cell (HSC) dormancy is understood as supportive of HSC function and its long-term integrity. Although regulation of stress responses incurred as a result of HSC activation is recognized as important in maintaining stem cell function, little is understood of the preventive machinery present in human HSCs that may serve to resist their activation and promote HSC self-renewal. We demonstrate that the transcription factor PLAG1 …
Authors
Chahi AK; Belew MS; Xu J; Chen HTT; Rentas S; Voisin V; Krivdova G; Lechman ER; Marhon SA; De Carvalho D
Journal
Blood, Vol. 140, No. 9, pp. 992–1008
Publisher
American Society of Hematology
Publication Date
September 1, 2022
DOI
10.1182/blood.2021014698
ISSN
0006-4971