Journal article
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
Abstract
The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific …
Authors
Young WJ; Lahrouchi N; Isaacs A; Duong T; Foco L; Ahmed F; Brody JA; Salman R; Noordam R; Benjamins J-W
Journal
Nature Communications, Vol. 13, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-022-32821-z
ISSN
2041-1723