Journal article
Tolerance to the hyperthermic effect of morphine in the rat is a learned response
Abstract
The results of several experiments indicated that the hyperthermic effect of morphine in rats becomes attenuated over the course of successive administrations by a conditional, compensatory, hypothermic response elicited by cues present at the time of morphine administration, thus accounting for hyperthermic tolerance: (a) Rats with a history of morphine administration display a tolerant response to the hyperthermic effect of the drug and a …
Authors
Siegel S
Journal
Journal of Comparative and Physiological Psychology, Vol. 92, No. 6, pp. 1137–1149
Publisher
American Psychological Association (APA)
Publication Date
December 1978
DOI
10.1037/h0077525
ISSN
0021-9940