Journal article
The Role of Formalin-Induced Pain in Morphine Tolerance, Withdrawal, and Reward
Abstract
The effect of a commonly used experimental pain-induction procedure (formalin injection into a hindpaw site) on morphine tolerance, withdrawal, and reward was examined in rats. Results suggest that the effects of morphine are different in the organism that is experiencing pain at the time it receives the drug than in the organism that is pain free. The presence of pain at the time of each morphine administration decreased analgesic tolerance, …
Authors
Bardin L; Kim JA; Siegel S
Journal
Experimental and Clinical Psychopharmacology, Vol. 8, No. 1, pp. 61–67
Publisher
American Psychological Association (APA)
Publication Date
2 2000
DOI
10.1037/1064-1297.8.1.61
ISSN
1064-1297