The development of the interictal spike during kindling in the rat

An attempt was made to determine the location of the generator(s) of interictal discharge in the kindled rat preparation. Animals were kindled by stimulation of hippocampal area CA3, fornix/fimbria, perforant path, amygdala or lateral olfactory tract. The development of interictal discharge was monitored in the intact preparation, and hippocampal slices were subsequently taken from both kindled and control animals. Contrary to our initial …