Journal article
Chronic Lithium Treatment Inhibits Pilocarpine-Induced Mossy Fiber Sprouting in Rat Hippocampus
Abstract
Lithium remains the gold standard in the treatment of bipolar disorder. Long-term treatment with lithium may lead to specific adaptational changes in gene expression that contribute to a neuroprotective effect. In this study, the pilocarpine model of spontaneous limbic epilepsy was used to induce mossy fiber sprouting (axonal growth of the dentate granule cells that synapse on the pyramidal cells of the CA3 region) to examine the prophylactic …
Authors
Cadotte DW; Xu B; Racine RJ; MacQueen GM; Wang JF; McEwen B; Young LT
Journal
Neuropsychopharmacology, Vol. 28, No. 8, pp. 1448–1453
Publisher
Springer Nature
Publication Date
8 2003
DOI
10.1038/sj.npp.1300189
ISSN
0893-133X