Journal article
Tamoxifen Derivatives for Delivery of the Antitumoral (DACH)Pt Group: Selective Synthesis by McMurry Coupling, and Biochemical Behaviour
Abstract
The goal of our study was to potentiate the effects of the ((R,R)-trans-1,2-diaminocyclohexane)-platinum(II) fragment [(DACH)Pt], known for its cytotoxic properties, either with tamoxifen (Tam), the most widely used antiestrogen in the treatment of hormone-dependent breast cancers, or with its active metabolite hydroxytamoxifen (hydroxy-Tam). We coupled Tam or hydroxy-Tam derivatives bearing a malonato group at the para position of the beta …
Authors
Top S; Kaloun EB; Vessières A; Leclercq G; Laïos I; Ourevitch M; Deuschel C; McGlinchey MJ; Jaouen G
Journal
ChemBioChem, Vol. 4, No. 8, pp. 754–761
Publisher
Wiley
Publication Date
August 4, 2003
DOI
10.1002/cbic.200200550
ISSN
1439-4227