Journal article
Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands
Abstract
The syntheses, structures and biological evaluation of a series of cisplatin-like complexes containing bis(imidazole) derivatives - the so-called Joseph ligands - are described. Their cytotoxicity is discussed in terms of their polar surface area, rate of aquation, and lipophilicity. The X-ray crystal structure of the platinum diiodido derivative of dimethyl 2-(di(1H-imidazol-2-yl)methyl)malonate) is reported and compared to those of related …
Authors
Ravera M; Gabano E; Sardi M; Ermondi G; Caron G; McGlinchey MJ; Müller-Bunz H; Monti E; Gariboldi MB; Osella D
Journal
Journal of Inorganic Biochemistry, Vol. 105, No. 3, pp. 400–409
Publisher
Elsevier
Publication Date
March 2011
DOI
10.1016/j.jinorgbio.2010.12.002
ISSN
0162-0134