Journal article
Antioxidant protection from HIV-1 gp120-induced neuroglial toxicity
Abstract
BackgroundThe pathogenesis of HIV-1 glycoprotein 120 (gp120) associated neuroglial toxicity remains unresolved, but oxidative injury has been widely implicated as a contributing factor. In previous studies, exposure of primary human central nervous system tissue cultures to gp120 led to a simplification of neuronal dendritic elements as well as astrocytic hypertrophy and hyperplasia; neuropathological features of HIV-1-associated dementia. …
Authors
Walsh KA; Megyesi JF; Wilson JX; Crukley J; Laubach VE; Hammond RR
Journal
Journal of Neuroinflammation, Vol. 1, No. 1,
Publisher
Springer Nature
Publication Date
2004
DOI
10.1186/1742-2094-1-8
ISSN
1742-2094