Journal article
Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes
Abstract
A recurrent chromosomal translocation found in acute myeloid leukemia leads to an in-frame fusion of the transcription repressor ZMYND11 to MBTD1, a subunit of the NuA4/TIP60 histone acetyltransferase complex. To understand the abnormal molecular events that ZMYND11-MBTD1 expression can create, we perform a biochemical and functional characterization comparison to each individual fusion partner. ZMYND11-MBTD1 is stably incorporated into the …
Authors
Devoucoux M; Fort V; Khelifi G; Xu J; Alerasool N; Galloy M; Wong N; Bourriquen G; Fradet-Turcotte A; Taipale M
Journal
Cell Reports, Vol. 39, No. 11,
Publisher
Elsevier
Publication Date
June 2022
DOI
10.1016/j.celrep.2022.110947
ISSN
2639-1856