Journal article
Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients
Abstract
The TP53 gene is mutated in approximately 60% of all colorectal cancer (CRC) cases. Over 20% of all TP53-mutated CRC tumors carry missense mutations at position R175 or R273. Here we report that CRC tumors harboring R273 mutations are more prone to progress to metastatic disease, with decreased survival, than those with R175 mutations. We identify a distinct transcriptional signature orchestrated by p53R273H, implicating activation of oncogenic …
Authors
Hassin O; Nataraj NB; Shreberk-Shaked M; Aylon Y; Yaeger R; Fontemaggi G; Mukherjee S; Maddalena M; Avioz A; Iancu O
Journal
Nature Communications, Vol. 13, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-022-30481-7
ISSN
2041-1723