Journal article
Biogeographic Variation and Functional Pathways of the Gut Microbiota in Celiac Disease
Abstract
BACKGROUND & AIMS: Genes and gluten are necessary but insufficient to cause celiac disease (CeD). Altered gut microbiota has been implicated as an additional risk factor. Variability in sampling site may confound interpretation and mechanistic insight, as CeD primarily affects the small intestine. Thus, we characterized CeD microbiota along the duodenum and in feces and verified functional impact in gnotobiotic mice.
METHODS: We used 16S rRNA …
Authors
Constante M; Libertucci J; Galipeau HJ; Szamosi JC; Rueda G; Miranda PM; Pinto-Sanchez MI; Southward CM; Rossi L; Fontes ME
Journal
Gastroenterology, Vol. 163, No. 5, pp. 1351–1363.e15
Publisher
Elsevier
Publication Date
November 2022
DOI
10.1053/j.gastro.2022.06.088
ISSN
0016-5085