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Journal article

Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants

Abstract

Importance: Dose-reduced regimens of direct oral anticoagulants (DOACs) may be used for 2 main purposes: dose-adjusted treatment intended as full-intensity anticoagulation (eg, for stroke prevention in atrial fibrillation [AF] in patients requiring dose reduction) or low-intensity treatment (eg, extended-duration treatment of venous thromboembolism [VTE]). We reviewed randomized clinical trials (RCTs) to understand the scenarios in which …

Authors

Bikdeli B; Tajrishi FZ; Sadeghipour P; Talasaz AH; Fanikos J; Lippi G; Siegal DM; Eikelboom JW; Monreal M; Jimenez D

Journal

JAMA Cardiology, Vol. 7, No. 7, pp. 747–759

Publisher

American Medical Association (AMA)

Publication Date

July 1, 2022

DOI

10.1001/jamacardio.2022.1292

ISSN

2380-6583