Journal article
In vitro assessment of the biocompatibility of chemically treated silicone materials with human lens epithelial cells
Abstract
Cytotoxicity testing is a regulatory requirement for safety testing of new ocular implants. In vitro toxicity tests determine whether toxic chemicals are present on a material surface or leach out of the material matrix. A method of evaluating the cytotoxicity of ocular implants was developed using fluorescent viability dyes. To assess the assay’s sensitivity in detecting toxic substances on biomaterials, zinc diethydithiocarbamate (ZDEC) and …
Authors
Kao ECY; Seo J; McCanna DJ; Subbaraman LN; Jones LW
Journal
Scientific Reports, Vol. 12, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41598-022-08443-2
ISSN
2045-2322